Evaluation of peripheral circulation in diffuse parenchymal lung disease patients using nailfold capillaroscopy
Evaluation of peripheral circulation in diffuse parenchymal lung disease patients using nailfold capillaroscopy
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Abstract Background One of the most recognized respiratory manifestations of connective tissue diseases is diffuse parenchymal lung disease, which may cause substantial morbidity and mortality.Since nailfold capillaroscopy is considered the most effective method for examining nailfold capillaroscopic changes that are commonly observed in a number of connective tissue-related disorders, it may be able to assist specialists in recognizing autoimmune characteristics or preliminary signs of connective tissue disorders in patients with diffuse parenchymal lung disease.The purpose of our research was to determine how nailfold capillaroscopy can be used to evaluate peripheral circulation in individuals with diffuse parenchymal lung disease.A cohort study included66 patients: 60 females and 6 males aged between 20 and 80 years with diffuse parenchymal lung disease, divided into Insulated Food/Beverage copyright Parts three groups: Group I: 27 patients with hypersensitivity pneumonitis (HP), Group II: included 18 patients with idiopathic interstitial pneumonia (IIP), and Group III: 21 patients with connective tissue-related interstitial lung disease (CTD-ILD).All patients in this study were subjected to full medical history, clinical examination, spirometry, HRCT chest with assessment of fibrosis by Warrick score, 6MWT, nailfold capillaroscopy, and ANA test.
Results In our research, we observed that capillaroscopic abnormalities were more frequent in the CTD-ILD and idiopathic ILD groups compared to the HP group.Major abnormalities appeared in the majority of patients within these two groups.Interestingly, all patients who showed normal nailfold capillaroscopic findings were from the HP group.Antinuclear antibody results were positive in 71.4% of CTD-related ILD cases, whereas the other groups presented negative results.
We also noted a higher prevalence of bizarre capillaries, avascular areas, giant capillaries, microhemorrhages, and bushy capillaries in patients with scleroderma-related ILD.Conversely, a greater percentage of tortuous capillaries was found in RA-related ILD cases, and avascular areas were Rug Proofer observed in all cases of interstitial pneumonia with autoimmune features (IPAF).From these findings, we conclude that nailfold capillaroscopic abnormalities are more common in patients with CTD-ILD, particularly those with scleroderma-related ILD, than in those with rheumatoid arthritis-related ILD, idiopathic ILD, and HP.